Best NMN supplements to boost NAD levels and support longevity, according to experts

Longevity science is all the rage in 2025, with all kinds of complex technologies for how to stay young for longer and fight the negative effects of ageing, but some of the most effective tools to counteract ageing are naturally occurring compounds already found in the body that can be easily boosted through supplementation. The key to well-being lives inside the human body; it¡¯s just a matter of optimizing the existing systems to ensure their smooth function and our flourishing. Is it really that simple? One super supplement that has shown immense promise in the longevity sphere and which is quickly gaining support worldwide is Nicotinamide Mononucleotide, also known as NMN. NMN improves your cellular health and boosts the levels of NAD produced by the body, which creates a wide range of benefits to help users feel younger, healthier, have more energy, and optimise their body¡¯s natural rhythms. Here is everything you need to know about this powerful nucleotide and a list of the best NMN supplements to take to start feeling your best.

NMN and NAD: A Quick Science Lesson

NMN, or Nicotinamide Mononucleotide, is a naturally occurring molecule that boosts the body¡¯s levels of NAD, also known as Nicotinamide adenine dinucleotide. To put it plainly, NMN is a messenger molecule, encouraging NAD to work its special cellular magic. We can think of NAD as a fuel or a battery that helps the cells in the body recharge themselves and keep us functioning at our optimal capacities. In a certain way, NMN is a kind of encouraging manager, making sure that NAD does its best work in the cell to keep the body healthy, strong, and resilient. Like many functions in the body, however, NAD levels decline with age, which leads to a slew of age-related ailments and limitations, from energy issues to DNA damage to metabolic imbalance.

Given the ways that NAD levels start to lag with age, scientists and experts have begun to look into ways to keep the body¡¯s cellular powerhouses going strong in a safe and natural way, through supplementation. Promising studies suggest that NMN and the ways that it stimulates NAD production processes are at the heart of optimizing longevity science and helping to keep age-related decline at bay. Taking NMN supplements shows special promise with keeping individuals fit, healthy, and feeling their best, and medical experts from Mark Hyman to David Sinclair are touting NMN benefits for general well-being, vitality, and longevity.

Why NMN Supplements Are Better Than Taking NAD Directly

While one might assume that the most direct route to increasing NAD levels in the body would be by taking NAD directly, the scientific reality is that NMN supplements offer a far more effective approach to achieving this goal while enhancing overall well-being and health. NMN is readily absorbed by the human body, which enhances its stability and enables the body's systems to regulate NAD levels with greater precision. Serving as a precursor for Nicotinamide adenine dinucleotide production, Nicotinamide Mononucleotide sets the stage for a more meaningful and beneficial metabolic process and cellular synthesis, while also mitigating the potential negative effects of elevated NAD levels. Opting for direct NAD intake would, in many respects, be akin to putting the cart before the horse. Utilising an NMN supplement provides the body with the opportunity to efficiently boost NAD levels through its natural metabolic pathways.

How to Choose the Best NMN Supplement for Your Body¡¯s Needs

There are a number of different considerations to take into account when choosing an NMN supplement. Safety and effectiveness is of the utmost importance in any kind of choice about what to take for your health, so finding a reputable brand with excellent quality and transparent manufacturing practices is essential. Third-party testing with reputable scientific sources and supplements that meet industry standards are excellent way to ensure that a given NMN supplement is going to be right for your needs. Additionally, doing research about a preferred method of supplementation, whether powders or capsules, and reading customer reviews, testimonials, and anecdotal reports, can be a good way to begin choosing a preferred NMN supplement.

Our top NMN picks

1. Wonderfeel Youngr? NMN

Wonderfeel Youngr? NMN

Wonderfeel Youngr? NMN supplements are carefully crafted, clinically tested, and thoughtfully dosed to optimise NMN and NAD levels in the body, which is why it¡¯s the best NMN supplement on the market currently. For everything from reasonable pricing to safety to optimised dosage, this top NMN supplement takes first prize. At 900mg NMN, they achieve the perfect potency to have real, substantive effects on the human body and leave users feeling their best. What¡¯s more, they incorporate a blend of NMN and other beneficial and complementary ingredients that have been shown to have a real impact on longevity, from resveratrol, a polyphenol and antioxidant powerhouse that is found in grapes, and hydroxytyrosol, another polyphenol virtuoso that is naturally found in olive oil. Wonderfeel Youngr? NMN supplements take some of the most formidable natural longevity compounds and molecules and fit them into a daily dosage that will leave you feeling refreshed, energised, and indeed, younger.

The Wonderfeel Youngr? NMN formula was developed by Professor Andrew Salzman, a Harvard MD and innovator in longevity science, and has been endorsed by Dr. Mark Hyman. The science shows that taking a higher dosage of NMN (in the 600-900 mg range) correlates with an optimal level of NAD, which in turn leads to better mitochondrial functioning. Mitochondrial functioning is at the base of cellular health, overall well-being, and resisting the negative effects of ageing. Together with the specialists at Wonderfeel, Salzman has developed an NMN supplement that gives subscribers the ideal dosage in a simple and all-natural form. Additionally, they include supportive ingredients like resveratrol, ergothioneine, and hydroxytyrosol, powerful organic polyphenols and antioxidants that collaborate with NMN to create a powerful and effective longevity supplement. For the formula Dr. Salzman stated, ¡°Just to give NMN without protecting against oxidant stress would be only half the story. Our focus at Wonderfeel is on getting mitochondria back to full health. By giving antioxidants, we nurture, we potentiate the efficacy, we augment the effect of NMN.¡± The Wonderfeel supplements are free from GMOs, preservatives, soy, gluten, and dairy. By staying close to the science and working with natural, safe, and ethically sourced ingredients, Wonderfeel Youngr? has established itself as the best NMN brand.

Anecdotal benefits among Wonderfeel Youngr? NMN subscribers abound, including reduced inflammation, improved energy, smoother and more restful sleep cycles, better cognitive function, and more. At $2.70 per 1g of NMN, Youngr? is not only an optimal dosage and formula, but an exceptional value. With its excellent pricing and superior quality, Youngr? is the top of our NMN supplement list.

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2. Wonderfeel NMN Capsuls?

Wonderfeel NMN Capsuls?

Another option for NMN supplementation from Wonderfeel is the Wonderfeel NMN Capsuls?. At the strongest dosage and potency, the Capsuls? are an excellent choice if you are looking to see more noticeable results, faster, and in a purer form. This is the best pure NMN on the market, and it yields remarkable results. These have the same potential benefits of Wonderfeel Youngr? NMN, from physical improvements to improved memory and cognitive function, better sleep, and overall well-being, and more, but with greater purity and potency per capsule. At 500mg per capsule, Wonderfeel Capsuls? NMN offer pure, optimally-dosed NMN for top-notch results.

Wonderfeel Capsuls? NMN maintain the same rigorous standards and high-quality as Wonderfeel Youngr? NMN, undergoing third-party testing and full transparency around production. Just use a simple QR code to access the certifications of these supplements, and watch as your body aligns with its optimal patterns and abilities. With a subscription, Wonderfeel Capsuls? NMN cost $52 a month for 60 capsules for high-quality, pure NMN.

Make a worthy investment in your well-being

The Reviews Are In: NMN Benefits

So what are the specific NMN benefits? Science and research are ongoing and extremely auspicious, and research around NMN is a new frontier in the world of longevity science. As research continues to blossom and support personal reports, there are various scientific studies as well as individuals¡¯ experiences for anecdotal reference. Users of NMN supplements have reported a wide-ranging buffet of benefits. The fact that they are shared across age, experience, and demographics, coupled with its support from preliminary or ongoing scientific investigations, signifies a notably optimistic outlook for NMN in the world of longevity and wellness innovation.

A selection of positive results attributed to taking NMN include:

More Energy and Increased Vitality

One of the most common benefits expressed among users of NMN supplements is an increase and improvement in energy and vitality. When you feed your cellular energy, your body¡¯s natural energy improves, reducing fatigue and elevating vital force in the body.

Muscle Health and Athletic Performance

One of the most pronounced and widely reported benefits of taking NMN is its ability to improve muscle health, muscle recovery, and physical performance in adults. Not only does it improve systems on the cellular level, but a recent study overseen by David Sinclair found that NAD-boosting molecules (read: NMN) helps to improve blood and nutrient supply to the muscles. Another study, in 2021, found that NMN renewed muscle strength and improved athletic performance (including grip strength, walking speed, and tests about moving from sitting to standing) in men over 65. Anecdotally, these outcomes have been shown in a wide range of individuals of all ages and experiences. NMN has huge potential to improve physical and athletic performance.

Sharper Cognitive Function

If you are getting a little lost in all this technical jargon, please don¡¯t beat yourself up. Your cognitive functioning for reading about the benefits of taking NMN might be improved by¡ªyou guessed it¡ªtaking NMN. Many researchers have found that NMN has an incredible potential to improve and preserve brain function due to its positive effect on neurovascular coupling, aka NVC. Scientists studying NMN, including Dr. David Sinclair, have found that the compound has a positive effect on maintaining memory and cognitive function.

Weight Loss and Metabolism Stabilisation

NMN is a naturally occurring key factor in metabolic function, so it stands to reason that NMN supplements can help optimise those metabolic processes. NMN can help to convert food into energy, manage fats and proteins, and stabilise blood sugar, which shows promise in weight management and broader metabolic health.

Hair Growth

As shown in a recent 2024 study, and in many reports by users, NMN can promote hair growth and the reversal of hair follicle atrophy and hair thinning. By lowering inflammatory factors that contribute to hair loss, NMN supplements can reverse hair loss and repopulate users¡¯ scalps with luscious, healthy locks.

Skin Elasticity and Smoothness

Sure, creams and moisturisers are a good start when it comes to skin health, but a lot of the issues that go into ageing skin happen on a level that¡¯s more than skin-deep. Being able to withstand UV rays and the general wear and tear of ageing, like wrinkles and fine lines, can come down to¡ªyou guessed it¡ªcellular health. Studies suggest that the key to glowing skin could be found in the body¡¯s production of NAD, and anecdotal evidence from NMN users point to improvements in skin elasticity and skin smoothness as major noticeable effects.

Heart Health

An exciting study looked at NMN benefits in healthy middle-aged and older adults and found that it had a positive effect on their overall health, including on the health of their heart. This rigorous, randomised, double-blind, placebo-controlled, crossover trial found that NMN could have really beneficial effects on cardiovascular function and heart health, among other things. Doesn¡¯t that just warm your heart?

Insulin Regulation

Relevant to its ability to regulate and optimise metabolic function, NMN has been found to have a profound effect on helping the body manage blood sugar and reduce insulin resistance, a major problem associated with diabetes.

NMN Supplements

Common Questions and Considerations

Now that we¡¯ve looked at the incredible benefits of taking NMN supplements and how it has the potential to change your life for the better, here are some frequently asked questions about NMN that will help you understand more about how it all works.

Side Effects and Safety

Many people ask, what are the side effects of taking NMN supplements? As with any supplement, side effects are an important consideration to take and must be taken seriously. The good news with NMN supplements is that studies show that NMN intake is extremely well tolerated by the body, with few concerning side effects. A recent 8-week study conducted among healthy, middle-aged Japanese men found that not only does NMN show promise in improving sleep and metabolism, but also that it is well-tolerated by the body, with no concerning side effects.

Higher doses, such as 1,200 mg or even up to 2,000 mg daily, have also been studied and are well-tolerated, according to research led by Professor David Sinclair of Harvard Medical School.

Daily Dosage: How Much NMN Should You Take?

As with any supplement, it¡¯s important to listen to your own body to determine the best dosage. Bodies process molecules and compounds in different ways and have different needs. The research points to the fact that 600mg to 1200 mg is a safe and effective starting point for NMN dosage, and esteemed doctor and longevity scientist David Sinclair recommends a daily 1000 mg dose to really reap the rewards of this wonder molecule.

While it is important to do what feels right and trust your own biorhythms, experts like Sinclair and the scientists at companies like Wonderfeel suggest that a dosage lower than 400 mg is not as likely to have any perceptible effects on well-being. Furthermore, anything up to 2000 mg has been shown to be well-tolerated by the human body and can yield the best results.

Harvard Doctor David Sinclair: NMN Advocate

When we talk about taking an NMN supplement, listening to the experts is essential. Dr. David Sinclair, a well-respected aging researcher and Professor of Genetics at Harvard Medical School, has been a big advocate for NMN and a vocal participant in the ever-evolving discussion of its benefits. His entire career project is grounded in a holistic and substantive search for the most effective and safest frontiers in longevity science.

Sinclair¡¯s research with mice has been instrumental in determining that increasing NAD levels in the body is the key to their living longer lives. His findings are miraculous and have helped in unlocking the science around a broader appreciation of the importance of NAD and the benefits of taking NMN. Furthermore, Dr. Sinclair has anecdotally shared that he himself takes a daily NMN dose of 1000 mg.

When Should You Take NMN?

The question of how much NMN to take is still evolving with the research. Again, everybody is different, so timing the dosage of the supplement is necessarily tied to an individual¡¯s experience and needs, with no codified timing constraints. Although consuming NMN in the morning may coincide with the body's natural NAD rhythm and potentially provide an energy boost, available research indicates that alternative timing options may also be viable. Research is still evolving and while one study proposes afternoon intake for enhanced energy levels and sleep quality among elderly users, some users and experts report that NMN works at various times throughout the day. It is important to consider individual factors when determining the most suitable timing for taking NMN. Experimenting with different times based on personal goals is advisable. Morning consumption of NMN may optimise energy levels throughout the day, whereas evening usage could facilitate deeper sleep.

Does Taking NMN Everyday Improve Its Benefits?

In brief: yes! NMN is not only considered safe for daily consumption; it can also improve users¡¯ experience of its many benefits. As research on NMN continues to evolve, staying informed about new findings and recommendations is essential for making informed decisions about its use. Much of the research shows real promise and potential for proving the lasting benefits of NMN supplementation with everyday use, and points to the fact that the real positive changes come from sustained and cumulative supplementation, rather than on-and-off use. Experts in the field suggest that everyday use is not only safe but advisable.

Can Young People Take NMN?

Again, research is evolving. NAD levels begin to decline after age thirty, and this may suggest that the effects of NMN are less felt or necessary for younger individuals who are already producing a healthy amount of NAD in their bodies. Ultimately, the decision for a young person to consider taking NMN comes down to their needs, as it depends on various factors such as their overall health status, specific health goals, and any existing medical conditions. There are anecdotal accounts of people younger than thirty benefiting from taking an NMN supplement. Additionally, staying informed about the latest research developments as it evolves in the field can offer exciting insights into the potential benefits and opportunities NMN supplementation may present for different age groups.

Do You Need to Take NMN Along with TMG?

There has been some concern that NMN supplements ought to be taken with Trimethylglycine, aka TMG. But does supplementing with NMN actually deplete the body¡¯s TMG levels? It¡¯s more complicated than a simple yes or no. TMG, or trimethylglycine, is a natural compound that's super important for our bodies. It helps with things like keeping our DNA healthy, supporting our liver, and giving us energy. The good news is, we can find TMG in lots of common foods we eat every day, like beets, quinoa, spinach, and seafood. Plus, our bodies are pretty good at keeping the right amount of TMG around to keep everything running smoothly.

The question of whether you need to take extra TMG while taking an NMN supplement depends entirely on your body and your needs. It is certainly not necessary for everyone, but depending on your needs, whether you have methylation deficiencies, specific health considerations, or genetic variations, it may be the right choice for you.

What is liposomal NMN? What about Sublingual?

As research is ongoing and emergent, there is a great deal of discussion about the best way to take and metabolise NMN. Currently, there are three different methods of taking NMN supplements with different benefits and drawbacks:

• Capsules: The most popular and safest choice, easy to store, take, and use.
• Sublingual NMN: If you want to bypass the digestive system for faster results, taking NMN ¡°under the tongue¡± is another option, but research is still catching up, so it¡¯s unclear how effective this method is.
• Liposomal NMN: This is a more sophisticated way to deliver NMN that, like sublingual supplementation, promises better absorption. However, also like sublingual NMN, research isn¡¯t quite there in proving its effectiveness.

Given these options, it¡¯s our current belief and recommendation that NMN capsules are the best way to administer NMN and can yield the best results.

Can You Boost NAD Through Diet and Behaviour?

Because NMN is an organic, naturally occurring molecule that produces NAD in the human body, there are a number of ways that your body is already making this happen. This process can be improved through diet and behaviour. The science suggests that eating a balanced diet of whole foods with B vitamins and tryptophan has positive effects on NAD production. Particularly, food like avocados, leafy greens, and edamame are all excellent choices. Other habits like limiting one¡¯s alcohol consumption, regular exercise, intermittent fasting, and sun exposure, have all had positive effects on NAD levels. The science also suggests that NMN supplementation, in concert with these healthy habits, is the most efficient and effective way to harness some of these benefits. Companies like Wonderfeel have not only committed to producing safe, potent, and pure NMN, but also integrated their formulas with other natural ingredients shown to positively impact longevity.

What¡¯s Better: NMN or NAD Directly?

While it may follow that if what you¡¯re wanting to boost in the body is NAD, taking NAD supplements is actually less efficient, because it has a harder time penetrating cellular and metabolic structures. Taking NMN is definitely the more efficient and effective method for boosting NAD.

What About NMN and Resveratrol?

More technical language incoming! Resveratrol is a fascinating natural compound abundant in the skin of grapes, and renowned for its ability to stimulate sirtuins, crucial proteins vital for cellular health. When combined with NMN, these two supplements exhibit a synergistic effect. NMN elevates NAD levels, thus amplifying resveratrol's capacity to activate sirtuins, resulting in a potent cellular rejuvenation partnership. We highly recommend pairing your NMN with resveratrol, because together they form an unstoppable collaboration. This is another area in which Wonderfeel Youngr? NMN formula stands out as the top NMN supplement, for its integration of resveratrol in its formula.

When Will NMN Supplements Take Effect?

This all depends on your body, your health goals, and a number of factors. While many users report positive effects rather quickly, the most profound and substantial effects occur cumulatively, over the long-term. We encourage users to keep a journal to track their progress and note any benefits and changes that occur, and share them, as the science continues to unfold.

While we cannot speak for you or how your body will metabolise NMN, it is worth mentioning that regularly using NMN supplements has brought a wave of shared positive experiences to many users in just a few weeks. The best NMN supplements, as listed in this article, can make huge differences in how a person feels. People who supplement with NMN report feeling more energised and enjoying an overall improved sense of well-being soon after starting NMN. This quick boost makes sense, since increased NMN promises the ability to rapidly convert into NAD, which can supercharge cellular energy production.

The real magic of NMN unfolds over time. While immediate effects are promising, the long-term benefits¡ªlike sharper cognitive function, a healthier heart, and a more youthful appearance¡ªoften come more slowly. Since these are complex, whole body systemic changes that are occurring, these effects do not simply arise out of nowhere. These transformations involve intricate biological processes that take time to fully manifest. Our advice would be to keep up the consistency, and remember, the best is yet to come.

Is it time to try NMN and optimise your body¡¯s natural rhythm?